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Catalogue
Number
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Product
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Order number / Unit
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2060
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(S)-(-)-Normethylcarbamoyl-GR 103545
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2060.0001: 1 mg per vial
2060.0003: 3 mg per vial
2060.0010: 10 mg per vial
Please inquire for customized
filling and bulk quantities.
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Precursor for (R)-(-)-[11C]-GR 103545
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Molar Mass: 356.29
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C17H23Cl2N3O
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[260992-21-0]
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Yellowish oil packaged in dark glass crimp cap vials.
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Purity: > 95 %
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Certificates:
CoA; 1H and 13C NMR spectra
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Chemical Name:
CA index name: Ethanone, 2-(3,4-dichlorophenyl)-1-[(2S)-2-(1-pyrrolidinylmethyl)-1-piperazinyl]-
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Synonymes:
(2S)-2-(3,4-Dichlorophenyl)-1-(2-pyrrolidin-1-ylmethyl-piperazine-1-yl)-ethanon; (2S)-1-[(3,4-Dichlorophenyl)acetyl]-2-(1-pyrrolidinymethyl)piperazine
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Literature:
Ravert H.T. et al. [11C]-GR 89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nuc. Med. Biol. 2002, 29, 47-53.
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Talbot P.S. et al. 11C-GR 103545, a Radiotracer for Imaging κ-Opioid Receptors In Vivo with PET: Synthesis and Evaluation in Baboons. J. Nucl. Med. 2005, 46, 484-494.
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Naylor A. et al. A Potent New class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines. J. Med. Chem. 1993, 36, 2075-2083.
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Schoultz B.W. et al. A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR 103545. The Open Med. Chem. J. 2008, 2 ,72-74.
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Nabulsi N.B. et al. [11C]GR103545: novel one-pot radiosynthesis with high specific activity. Nucl. Med. Biol. 2011, 38, 215-21.
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date of product catalogue issue:
10 May 2017
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