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Catalogue
Number
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Product
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Order number / Unit
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2072
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(S)-(+)-GR89696 fumarate
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2072.0001: 1 mg per vial
2072.0005: 5 mg per vial
2072.0010: 10 mg per vial
Please inquire for customized
filling and bulk quantities.
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Reference standard for (S)-(+)-[11C]GR89696
Less active enantiomer of the selective kappa opioid receptor agonist GR89696
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Molar Mass: 530.40
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C19H25Cl2N3O3 ⋅ C4H4O4
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[150133-21-4]
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Off-white solid packaged in dark glass crimp cap vials.
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Purity: > 95 %
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Certificates:
CoA; 1H and 13C NMR spectra
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Chemical Name:
1-Piperazinecarboxylic acid, 4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester, (S)-, (E)-2-butenedioate (1:1)
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Synonymes:
(S)-(+)-GR89696 fumarate salt; (S)-4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
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Literature:
Ravert H.T. et al. [11C]-GR 89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nuc. Med. Biol. 2002, 29, 47-53.
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Talbot P.S. et al. 11C-GR 103545, a Radiotracer for Imaging κ-Opioid Receptors In Vivo with PET: Synthesis and Evaluation in Baboons. J. Nucl. Med. 2005, 46, 484-494.
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Naylor A. et al. A Potent New class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines. J. Med. Chem. 1993, 36, 2075-2083.
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Schoultz B.W. et al. A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR 103545. The Open Med. Chem. J. 2008, 2 ,72-74.
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date of product catalogue issue:
10 May 2017
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