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Catalogue Number |
Product | Order number / Unit |
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| 3371 | ASEM precursor |
3371.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities. 
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Precursor for [18F]ASEM
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| Molar Mass: 385.44 | ||
| C19H19N3O4S | ||
| [1456877-71-6] | ||
| Reddish solid packaged in dark glass crimp cap vials. | ||
| Purity: > 95 % | ||
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Certificates:
CoA; 1H spectrum |
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Chemical Name: 3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-nitrodibenzo[b,d]thiophene 5,5-dioxide |
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Synonymes: [18F]ASEM precursor; [18F]JHU82132 precursor; 4-(6-Nitro-5,5-dioxo-5H-5l6-dibenzothiophen-3-yl)-1,4-diaza-bicyclo[3.2.2]nonane |
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Literature: Gao Y. et al. Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors. J. Med. Chem. 2013, 56, 7574-7589. |
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| Horti A.G. et al. 18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET. J. Nucl. Med. 2014, 55, 672-677. | ||
| Wong D.F. et al. Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy. Mol. Imaging Biol. 2014, 16, 730-738. | ||
| Horti A.G. Development of [18F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography. Biochem. Pharmacol. 2015, 97, 566-575. | ||
| Ravert H.T. et al. Microwave-assisted radiosynthesis of [18F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist. J. Labelled Compd. Radiopharm. 2015, 58, 180-182. | ||
| date of product catalogue issue: 10 May 2017 | ||