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Catalogue Number |
Product | Order number / Unit |
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| 9510 | PMPA |
Please inquire for customized filling and bulk quantities. 
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Inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase)
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| Molar Mass: 226.12 | ||
| C6H11O7P | ||
| [173039-10-6] | ||
| colourless highly viskous oil packaged in dark glass vials. | ||
| Bitte Patentschutz klären. | ||
| Purity: > 95 % | ||
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Certificates:
CoA; 1H NMR spectrum |
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Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid |
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Synonymes: PMPA (NAALADase inhibitor) |
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Literature: Jackson et al. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 1996, 39, 619 |
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| Slusher et al. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 1999, 5, 1396 | ||
| Thomas et al. NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 2003, 471, 177 | ||
| date of product catalogue issue: 10 May 2017 | ||