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Catalogue
Number
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Product
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Order number / Unit
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9714
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AMBA acetate
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9714.0001: 1 mg per vial
9714.0010: 10 mg per vial
Please inquire for customized
filling and bulk quantities.
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Molar Mass: 1502.70
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C68H99N19O18S
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[721937-56-0] (net peptide)
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Colourless to off-white freeze-dried solid packaged in screw cap vials.
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Purity: ≥ 97 %
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Certificates:
CoA; MS (identity); HPLC (purity)
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Chemical Name:
Sequence: DOTA-Gly-4-Abz-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
DOTA = N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-
4-Abz = 4-aminobenzoyl
Supplied as acetate salt
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Synonymes:
CA index name: L-Methioninamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]glycyl-4-aminobenzoyl-L-glutaminyl-L-tryptophyl -L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-
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Literature:
Chen J. et al. Synthesis, stabilization and formulation of [177Lu]Lu-AMBA, a systemic radiotherapeutic agent for Gastrin Releasing Peptide receptor positive tumors. Appl Radiat Isot. 2008, 66, 497-505.
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Waser B. et al. Selective in vitro targeting of GRP and NMB receptors in human tumours with the new bombesin tracer 177Lu-AMBA. Eur. J. Nucl. Med. Mol. Imaging. 2007, 34, 95-100.
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Lantry L.E. et al. 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. J. Nucl. Med. 2006, 47, 1144-52.
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Nunn A.D. et al. Preclinical evaluation of 177Lu-AMBA, a radiolabelled peptide for systemic radiotherapy and imaging of prostate cancer by targeting gastrin releasing peptide receptors. Eur. J. Cancer Suppl. 2004, 2, 89.
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date of product catalogue issue:
10 May 2017
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