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Catalogue
Number
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Product
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Order number / Unit
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9943
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PSMA-1007 precursor
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9943.0001: 1 mg per vial
9943.0002: 2 mg per vial
Please inquire for customized
filling and bulk quantities.
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Precursor for [18F]PSMA-1007
PSMA: prostate-specific membrane antigen
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Research Chemical
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Molar Mass: 1184.13
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C54H64F3N9O18
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CAS-RN not yet assigned
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Colourless to off-white solid packaged in dark glass crimp cap vials.
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Purity: > 95 %
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Certificates:
CoA; 1H NMR spectrum (identity); HPLC (purity)
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Chemical Name:
5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-N,N,N-trimethylpyridin-2-aminium 2,2,2-trifluoroacetate
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Synonymes:
deprotected [18F]PSMA-1007 precursor; Glu-CO-Lys(2Nal-Amb-Glu-Glu-PyTMA); EuK(2Nal-Amb-Glu-Glu-PyTMA); 5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-pyridin-2-yl-trimethylammonium 2,2,2-trifluoroacetate
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Literature:
Giesel F.L. et al. 18F-*PSMA-1007* PET/CT Detects Micrometastases in a Patient With Biochemically Recurrent Prostate Cancer. Clin. Genitourin. Cancer. 2016. doi: 10.1016/j.clgc.2016.12.029.
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Giesel F.L. F-18 labelled *PSMA-1007*: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur. J. Nucl. Med. Mol. Imaging 2017, 44(4), 678-688. doi: 10.1007/s00259-016-3573-4.
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Cardinale J. et al. Preclinical Evaluation of [18F]PSMA-1007: A New PSMA-Ligand for Prostate Cancer Imaging. J. Nucl. Med. 2016. doi: 10.2967/jnumed.116.181768
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Giesel F.L. et al. 18F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617. Eur. J. Nucl. Med. Biol. 2016, 43, 1929-30.
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Kesch C. et al. Intra-individual comparison of 18F-PSMA-1007-PET/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer - a retrospective, proof of concept study. J Nucl Med. 2017 doi: 10.2967/jnumed.116.18923
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date of product catalogue issue:
23 June 2017
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